Findings from 2 new studies, led by scientists at Kaiser Permanente Washington Health Research Institute (KPWHRI), show that many health care professionals are not following evidence-based guidelines for diagnosing hypertension and that automated office blood pressure monitors do not provide adequate information for assessments regardless of variations in the protocol that is used.
Beverly Green, MD, MPH, the lead investigator for both studies, presented the results at the Sept. 10-13 virtual Hypertension 2020 Scientific Sessions, organized by the American Heart Association. Dr. Green is a senior investigator at KPWHRI and a family physician at Washington Permanente Medical Group.
In the first study, Dr. Green and her colleagues conducted a survey of health care professionals that evaluated their knowledge, beliefs, and practices regarding hypertension diagnostic tests and how they were following professional guidelines.
The 2017 American Heart Association/American College of Cardiology Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults recommends the use out-of-office blood pressure measurements such as ambulatory blood pressure monitoring (ABPM) before making a new diagnosis of hypertension. ABPM involves a patient wearing a cuff that automatically checks blood pressure every 30 minutes during the day and every 60 minutes at night.
While ABPM as well as home blood pressure monitoring are recommended before diagnosing hypertension, the survey found that most health care professionals are using in-clinic measurements.
Dr. Greens’ research team surveyed 282 professionals across 10 primary care medical centers. The results indicate:
“We were surprised that blood pressure measurements taken manually with a cuff and stethoscope was the most trusted method, and most often used when making a new diagnosis of hypertension,” said Dr. Green.
The survey also shows that some health care professionals are not following evidence-based guidelines, potentially leading to under and overdiagnosis of hypertension.
“Most physicians and advanced practitioners thought the threshold for high blood pressure for 24-hour ambulatory or home blood pressure monitoring was >140/90 mm Hg, which does not reflect the updated new ACC/AHA (issued in 2017) or prior hypertension guidelines,” Dr. Green said. “Blood pressure measurements taken with automated devices in clinic or at home are more likely to be accurate."
According to the guidelines, hypertension should be defined as ≥130/80 mm Hg. Researchers noted that this study began before the updated ACC/AHA guidelines were released in 2017, and at that time, ≥140/90 mm Hg was the appropriate criteria. Limitations to this study include a small sample size, yet researchers note that having survey respondents from multiple centers helps to strengthen the sample.
Co-authors are Melissa Anderson, MS, Andrea Cook, PhD, Kelly Ehrlich, MS, Laurel Hansell, MPH, Clarissa Hsu, PhD, and Jennifer McClure, PhD, of KPWHRI; Sean Munson, PhD, Yoshio Hall, MD, MS, and Matthew Thompson, MBChB, MPH, DPhil, of the University of Washington; patient investigator Dwayne Joseph; and Karen Margolis, MD, MPH, of HealthPartners Institute. The study was funded by the Patient-Center Outcomes Research Institute.
In a second study, Dr. Green and colleagues examined how different protocols for using an automated office blood pressure (AOBP) monitor affected the ability to diagnose hypertension.
AOBP involves use of a monitoring device that automatically takes 3 to 5 BP measures during a patient’s visit to the clinic, as opposed to having a health care professional take a patient’s BP.
“In this study, we focused on investigating whether having an attendant in the room matters and on determining the impact of varying amounts of rest times on blood pressure using automated readings,” Dr. Green said. “We also evaluated the performance of AOBP monitors in making a new diagnosis of hypertension compared with 24-hour ambulatory blood pressure, which is considered the gold standard for deciding whether a patient has hypertension or not.”
The researchers found that AOBP was lower than the 24-hour ambulatory BP, which meant, on average, it would lead clinicians to think that a person had white coat phenomenon when they actually had higher blood pressure by the gold standard. “It overcorrected,” said Dr. Green adding that more resting time (15 vs 5 minutes) and attendance by a clinician did not change this overcorrection.
The study included 130 adults with high blood pressure (defined in this study as >140/90 mm Hg) who had no prior hypertension diagnosis or treatment. All participants completed 24-hour ambulatory blood pressure monitoring directly before starting the study, and more than 60% tested positive for hypertension based on these measures.
Participants were randomized to one of two groups: those who received AOBP with an attendant first and unattended second, and those who received unattended AOBP first and with an attendant second. The AOBP measurements were performed after five minutes of rest and again after 15 minutes.
Results showed that having an attendant in the room did not impact AOBP readings. Lack of resting prior to AOBP did result in a significantly higher blood pressure readings than the average daytime 24-hour ambulatory blood pressure. While, resting 5 minutes or more resulted in BP that was significantly lower than 24-hour ambulatory blood pressure.
“None of the variations on AOBP measurement -- no rest or 1-minute, 5-minutes, or 15- minutes rest --did that great at diagnosing hypertension because of blood pressure variability,” said Dr. Green. "Blood pressure varies a lot during the day; getting one set of blood pressures, often does not reflect a persons’ true blood pressure, which is the average of their blood pressure measurements throughout the day."
In addition, the study found:
“These findings indicate AOBP readings might not be the optimal way to rule in or rule out a new diagnosis of hypertension,” Dr. Green said. “You need more BPs.”
“When there is a question of whether blood pressure is high or normal, getting more blood pressure measurements, either by at-home testing or by getting a 24-hour ambulatory monitoring test, is likely to lead to better decision-making.”
In this study, an elevated blood pressure was defined as a blood pressure reading ≥140/90 mm Hg. According to the 2017 American Heart Association/American College of Cardiology Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults, hypertension should be defined as ≥130/80 mm Hg. Limitations to this study include a small sample size.
Co-authors are Melissa Anderson, MS, Andrea Cook, PhD, and Kelly Ehrlich, MS, of KPWHRI; Yoshio Hall, MD, MS, and Matthew Thompson, MBChB, MPH, DPhil, of the University of Washington; and Karen Margolis, MD, MPH, of HealthPartners Institute. The researchers reported no outside funding for this study.
This story is adapted from a news release produced by the American Heart Association for its virtual 2020 Hypertension Scientific Sessions, held Sept. 10-13, with additional comments provided by Dr. Green
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